New Twist on Popular Theory for the Origin of Life on Earth

There are multiple

theories

around the origin of life on

Earth

, but the most commonly accepted one is the “

RNA World

” theory, which posits that ribonucleic acid (RNA) was the precursor to deoxyribonucleic acid (

DNA

)—the basic building block today of all living organisms and many

viruses

. But scientists at

The Scripps Research Institute

(TSRI) in La Jolla, California, found a problem with that hypothesis. It led them to suggest that RNA and DNA evolved simultaneously.


Representation of the DNA double helix.


Credit: Wikipedia

“Even if you believe in a RNA-only world, you have to believe in something that existed with RNA to help it move forward,” said Ramanarayanan Krishnamurthy, associate professor of chemistry at TSRI and senior author of the new

study

.

DNA is the familiar double-helix of high school biology. RNA is essentially one side of the ladder. The problem with the RNA World theory is that, on the way from RNA to DNA, there would have been times when the two molecules blended, forming heterogenous strands. These strands, called chimeras, would be an intermediate step toward DNA. The Scripps researchers found these chimeras to be unstable. This finding supported previous research by Nobel Prize-winning biologist

Jack Szostak

of Harvard University.


Ram Krishnamurthy, associate professor of chemistry at The Scripps Research Institute.


Credit: TSRI

The instability of these chimeras means that they would have likely not survived. In modern cells, if RNA nucleotides accidentally join a DNA strand, sophisticated enzymes come in to fix the mistake. These enzymes weren’t around 3.8 billion years ago. “The transition from RNA to DNA would not have been easy without mechanisms to keep them separate,” said Krishnamurthy.



This led the scientists at TSRI to look at another possibility. “Why not think of RNA and DNA rising together, rather than trying to convert RNA to DNA by means of some fantastic chemistry at a prebiotic stage?” Krishnamurthy

said

.

If RNA and DNA evolved at the same time, RNA could still have evolved to produce DNA, but the two molecules would already have independent homogenous systems.

While this rocks the RNA World theory, it doesn’t offer any clues as to how those key molecules arose in the first place. But, back in May, a study

found

that the key ingredients to form RNA could have been present on the young Earth. Some of those compounds, including purine, adenine and guanine, could have been created when asteroids and comets crashed into Earth. Additionally, a

NASA study

showed how the building blocks of DNA could be made in space.

Although scientists will never know precisely how life on Earth began, understanding more about the mechanisms increases our knowledge of fundamental biology.

/res/community/twitter_embed/?iframe_id=twitter-embed-756967167178973184&created_ts=1469310011.0&screen_name=EcoWatch&text=Find+Out+How+Much+the+Earth+Has+Changed+Since+You+Were+Born+-+EcoWatch+https%3A%2F%2Ft.co%2FzoRrngIPhe+%40Greenpeace+%40HuffPostGreen&id=756967167178973184&name=EcoWatch

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s